Endocrine Abstracts

Introduction: Aldosterone (Aldo) decreases the rate of repolarization in rabbit cardiomyocytes and significantly increases the duration of the monophasic action potential in patients with supraventricular arrhythmias, few minutes after its intravenous administration, implying for a non-genomic action. We have previously found a positive linear regression between left ventricular systole duration and plasma Aldo levels in NZW rabbits. To investigate the veracity of the above fi...

Primary hyperparathyroidism is currently recognized with increasing frequency by routine calcium measurement in biochemical examinations. Primary hyperparathyroidism may be due to a parathyroid adenoma, parathyroid hyperplasia and, rarely, parathyroid carcinoma. Cinacalcet is used in the medical management of primary hyperparathyroidism.The aim was to assess the role of cinacalcet in the treatment of primary hyperparathyroidism.Pat...

Background: Childhood and adolescence are critical periods for the establishment of lifelong bone health. While most studies focus on vitamin-D regardless of PTH levels, Normocalcemic Primary Hyperparathyroidism (NPHPT) has been recognized more than 15 years ago as a variant of primary hyperparathyroidism (PHPT), characterized by persistently elevated PTH with normal albumin-adjusted total and ionized calcium, in the absence of secondary causes of hyperparathyroidism. PPHPT is...

Primary hyperparathyroidism is a rather frequent disorder characterized by high plasma PTH and calcium. Vitamin D deficiency is prevalent in all areas of the world. Vitamin D deficiency has been described in patients with primary hyperparathyroidism. When present, vitamin D deficiency may be associated with large size parathyroid adenomas and musculoskeletal pain.The aim was to describe two cases of primary hyperparathyroidism and vitamin D deficiency.</...

Acromegaly is known to be associated with increased cardiovascular risk. Additionally, acromegaly is known to be associated with disordered carbohydrate metabolism. Lipid levels in acromegaly have not been extensively studied. The aim was to study lipid levels in acromegaly.Methods: In 32 patients with newly diagnosed acromegaly lipid levels were studied. In particular total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride levels were measu...

Rheumatoid arthritis (RA) is known to be associated with cardiovascular comorbidity. In particular, patients with RA are known to be at increased for the development of atherosclerosis. Treatment with biological agents in RA may affect lipid levels.Aim: The aim was to study the effect of rituximab treatment on lipid levels in RA patients.Methods: In a cohort of 20 patients with RA lipid levels were studied before, 6 and 12 months a...

Although the prognosis of thyroid cancer is in general quite favorable when standard management paradigms are applied, some patients do much less well. Radioactive iodine refractory, recurrent or metastatic disease is prognostically more worrisome. Sorafenib, a multitargeted small molecule kinase inhibitor, including the VEGF receptor and BRAF kinase, has been evaluated in patients with thyroid cancer. The aim of the study was to present a case of metastatic thyroid cancer and...

Background: With the increasing use of cancer immunotherapies in advanced solid organ and hematologic malignancies, endocrinologists are beckoned to manage endocrine complications with unique presentations and natural history in the already challenged oncology patient. We describe four patients illustrating the multifarious endocrine adversities of checkpoint inhibitors.Cases: Patient 1 is a 35-year old male with refractory Hodgkin’s lymphoma, previ...

Introduction: The results of this epidemiological study demonstrate the burden of 25-hydroxyvitamin D deficiency in two sunny Mediterranean countries Greece and Cyprus- and some of the related risk factors. These two populations were examined together due to their common phylogenetic origin. Up until now there are no available data for the mean Vitamin D levels of the Cypriot adult population. An early identification of vitamin D deficiency is now considered as the cornerstone...

Objective: Vitamin D is a multifunctional hormone with possible antitumor effects. Its exact role in breast carcinogenesis remains largely unknown. We evaluated serum vitamin D levels in female patients with recently identified benign or malignant lesions of the breast and its associations with tumor histology.Subjects-methods: One hundred sixty women with suspicious breast masses that required surgical excision were included in this study. Body composit...